Search

Your search keyword '"Pyridazine -- Chemical properties"' showing total 2 results
Start Over Descriptor "Pyridazine -- Chemical properties" Journal biochemistry
2 results on '"Pyridazine -- Chemical properties"'

1. Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis

Author

Seiner, Derrick R., Hegde, Subray S., and Blanchard, John S.

Subjects
Catalysis -- Analysis, Mycobacterium tuberculosis -- Physiological aspects, Niacinamide -- Structure, Niacinamide -- Chemical properties, Nitriles -- Chemical properties, Pyridazine -- Structure, Pyridazine -- Chemical properties, Biological sciences, Chemistry
Abstract

The article explains various mechanisms that are involved in the catalysis and inhibition of nicotinamidase/pyrazinamidase (PncA) from Mycobacterium tuberculosis. Pyrazinecarbonitrile is shown to be one compound that acts as an irreversible inactivator of PcnA.

Published
2010

2. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

Author

Crowe, Alex, Huang, Wenwei, Ballatore, Carlo, Johnson, Ronald L., Hogan, Anne-Marie L., Huang, Ruili, Wichterman, Jennifer, McCoy, Joshua, Huryn, Donna, Smith, Amos B., Ingles, James, Auld, Douglas S., Trojanowski, John Q., Austin, Christopher P., Brunden, Kurt R., and Lee, Virginia M.-Y.

Subjects
Alzheimer's disease -- Genetic aspects, Alzheimer's disease -- Physiological aspects, Enzyme inhibitors -- Chemical properties, Enzyme inhibitors -- Structure, Fluorescence -- Evaluation, Pyridazine -- Chemical properties, Pyridazine -- Structure, Biological sciences, Chemistry
Abstract

A study was conducted to examine drug-like inhibitors of tau assembly using quantitative high-throughput screening (qHTS) of [approximately]292000 compounds. Findings revealed classes of inhibitors, including novel aminothienopyridazines (ATPZs).

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results