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3 results on '"Rabson, Arnold B."'

1. Drug targeting of HIV-1 RNA.DNA hybrid structures: Thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication

Author

Tsai-Kun Li, Barbieri, Christopher M., Hsin-Chin Lin, Rabson, Arnold B., Gengcheng Yang, Yupeng Fan, Gaffney, Barbara L., Pilch, Daniel S., and Jones, Roger A.

Subjects
Ribonuclease -- Structure, Reverse transcriptase -- Research, Thermodynamics -- Analysis, Biological sciences, Chemistry
Abstract

An approach for inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus type I (HIV-I) reverse transcriptase (RT) is demonstrated by targeting RNase H RNA.DNA hybrid substrates. In this approach the binding of the 4,5-disubstituted 2-deoxystreptamine aminoglycosides, neomycin, paromomycin and ribostamycin, to two different chimeric RNA-DNA duplexes inhibits specific RT-mediated RNase cleavage in competitive manner.

Published
2004

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