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Your search keyword '"Synold, Timothy W"' showing total 3 results
Start Over Author "Synold, Timothy W" Journal biochemistry
3 results on '"Synold, Timothy W"'

1. Similar mutagenicity of photo activated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: Involvement of oxidative DNA lesions in mutagenesis

Author

Besaratinia, Ahmad, Bates, Steven E., Synold, Timothy W., and Pfeifer, Gerd P.

Subjects
Porphyrins -- Chemical properties, Embryonic induction, Mutagenicity testing, Biological sciences, Chemistry
Abstract

An investigation of the mutagenicity of ultraviolet A (UVA) alone and in combination with gamma-aminolevulinic acid (gamma-ALA), a precursor of the intracellular photosensitizers porphyrins, in transgenic Big Blue mouse embryonic fibroblasts is conducted. It is concluded that in the presence of exogenous photosensitizers, UVA at a nonmutagenic dose induces mutations through the same mechanism, as does a mutagenic dose of UVA per se.

Published
2004

2. G-to-T transversions and small tandem base deletions are the hallmark of mutations induced by ultraviolet A radiation in mammalian cells

Author

Besaratinia, Ahmad, Synold, Timothy W., Bixin Xi, and Pfeifer, Gerd P.

Subjects
Mice as laboratory animals -- Research, DNA-ligand interactions -- Research, Ultraviolet radiation -- Research, Genetic research, Biological sciences, Chemistry
Abstract

The mutagenicity of ultraviolet A radiation (UV A) is investigated in relation to its DNA damaging effects in transgenic Big Blue mouse embryonic fibroblasts. UV A -induced mutations were characterized by statistically significant increases in G-to-T transversions and small tandem base deletions relative to spontaneously derived mutations.

Published
2004

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