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Start Over Author "Wang, Kangsheng" Journal biochemistry and cell biology
1 results on '"Wang, Kangsheng"'

1. Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression

Author

Zhang, Xue, Soong, Richie, Wang, Kangsheng, Li, Lin, Davie, James R., Guarcello, Vincenzo, and Diasio, Robert B.

Subjects
Drug therapy, Chemical properties, Physiological aspects, Genetic aspects, Oxidoreductases -- Chemical properties -- Genetic aspects -- Physiological aspects, Fluorouracil -- Chemical properties -- Physiological aspects, Dihydropyridine -- Chemical properties -- Genetic aspects -- Physiological aspects, Colorectal cancer -- Genetic aspects -- Drug therapy
Abstract

Dihydropyrimidine dehydrogenase (DPD) is one of the factors that determine the efficacy and toxicity of 5-fluorouracil. Variations in DPD activity may result from alterations at the transcriptional level of the [...]

Published
2007

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