1. Antitumor activity of conjugates of the oncofetal protein alpha-fetoprotein and phthalocyanines in vitro.
- Author
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Severin SE, Posypanova GA, Katukov VYu, Shmyrev II, Luzhkov YuM, Gerasimova GK, Zhukova OS, Vorozhtsov GN, Kaliya OL, Lukyanets EA, and Severin ES
- Subjects
- Aluminum toxicity, Antineoplastic Agents chemical synthesis, Antineoplastic Agents toxicity, Cobalt toxicity, Female, Humans, Immunotoxins toxicity, Indoles toxicity, Isoindoles, Lymphocytes drug effects, Neuroblastoma, Ovarian Neoplasms, Oxidants, Photochemical chemical synthesis, Oxidants, Photochemical toxicity, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Tumor Cells, Cultured, alpha-Fetoproteins toxicity, Antineoplastic Agents pharmacology, Immunotoxins pharmacology, Indoles pharmacology, Organometallic Compounds toxicity, alpha-Fetoproteins pharmacology
- Abstract
The several conjugates of aluminium and cobalt complexes of phthalocyanines with human alpha-fetoprotein have been synthesized. Their cytotoxic activity against tumor cells and human peripheral blood lymphocytes was studied. The experimental data demonstrate that the cytotoxic activity of alpha-fetoprotein-phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. The application of phthalocyanines as conjugates with alpha-fetoprotein makes it possible to markedly enhance the selective toxicity of phthalocyanines against human tumor cells.
- Published
- 1997
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