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1. Cyclic phosphorylation/dephosphorylation cascade in bovine brain coated vesicles.

Author

Pauloin A, Thurieau C, and Jollès P

Subjects
Animals, Cattle, Kinetics, Models, Biological, Molecular Weight, Phosphoprotein Phosphatases metabolism, Phosphorylation, Protein Kinases metabolism, Brain metabolism, Coated Pits, Cell-Membrane metabolism, Endosomes metabolism, Membrane Proteins metabolism
Abstract

Coated vesicles are involved in transport of membrane proteins between several intracellular membrane-bound compartments. These vesicles possess a specific 50-kDa protein which is phosphorylated and dephosphorylated by a coated-vesicle-specific kinase and phosphatase. We studied this phosphorylation/dephosphorylation cascade system and show that the phosphorylation level of the 50-kDa protein is governed by the ATP/ADP ratio.

Published
1988
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