1. Selective exposure of mucopolysaccharides is involved in macrophage physiology.
- Author
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Del Rosso M, Cappelletti R, Vannucchi S, Romagnani S, and Chiarugi VP
- Subjects
- Animals, Cell Membrane analysis, Cells, Cultured, Chondroitin Sulfates analysis, Dermatan Sulfate analysis, Electrophoresis, Cellulose Acetate, Female, Guinea Pigs, Heparitin Sulfate analysis, Hyaluronic Acid analysis, Male, Peritoneum, Glycosaminoglycans analysis, Macrophages analysis
- Abstract
Surface and intracellular mucopolysaccharides of guinea-pig peritoneal macrophages maintained in suspension and monolayer culture were studied. At least five classes of compound (hyaluronic acid, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate and chondroitin 6-sulfate) were resolved and characterized by electrophoresis and enzymatic degradation. The results reported here suggest that modulation of mucopolysaccharide exposure is involved in macrophage physiology. The possible biological role of surface mucopolysaccharides in macrophage activity is discussed.
- Published
- 1979
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