1. All three human ras genes are expressed in a wide range of tissues
- Author
-
Alan Hall and Gianna Fiorucci
- Subjects
Cell ,Biophysics ,Dot blot ,Biology ,Biochemistry ,Proto-Oncogene Proteins p21(ras) ,Structural Biology ,Ras gene family ,Proto-Oncogene Proteins ,Gene expression ,Proto-Oncogenes ,Genetics ,medicine ,Tumor Cells, Cultured ,Humans ,RNA, Messenger ,RNA, Neoplasm ,Gene ,Embryo, Mammalian ,Molecular biology ,Neoplasm Proteins ,Human tumor ,medicine.anatomical_structure ,Cell culture ,Organ Specificity ,Human fetal - Abstract
We examined the expression of the ras gene family (Ha-ras, Ki-ras, N-ras) in human fetal tissues (14 week) and in several human tumor cell lines. Dot blot hybridization showed that the three ras genes were expressed in all of the samples analysed, with a range of expression between 10 and 180 molecules/cell. There was no correlation between levels of expression of ras genes and the type of ras gene activated in different tumor types.
- Published
- 1988