1. Molecular trait of follicular-patterned thyroid neoplasms defined by MALDI-imaging
- Author
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Marcella Scardilli, Francesca Bono, Isabella Piga, Maria Grazia Valsecchi, Francesca Clerici, Davide Leni, Stefania Galimberti, Nicole A. Cipriani, Fabio Pagni, Giulia Capitoli, Virginia Brambilla, Valentina Canini, Fulvio Magni, Piga, I, Capitoli, G, Clerici, F, Brambilla, V, Leni, D, Scardilli, M, Canini, V, Cipriani, N, Bono, F, Valsecchi, M, Galimberti, S, Magni, F, and Pagni, F
- Subjects
0301 basic medicine ,MALDI imaging ,Adult ,Male ,Proteomics ,Biopsy, Fine-Needle ,Biophysics ,Thyroid fine needle aspiration biopsy ,Bioinformatics ,medicine.disease_cause ,Biochemistry ,Analytical Chemistry ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,MALDI-MSI ,Humans ,Thyroid Neoplasms ,Molecular Biology ,Thyroid tumors ,Thyroid neoplasm ,Aged ,Invasive carcinoma ,business.industry ,NIFTP ,Thyroid ,Middle Aged ,Carcinoma, Papillary ,030104 developmental biology ,medicine.anatomical_structure ,Transgender hormone therapy ,030220 oncology & carcinogenesis ,Papillary thyroid carcinoma ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Trait ,Female ,business - Abstract
In the field of thyroid neoplasms, the most interesting recent change regards the introduction of a new terminology for follicular-patterned thyroid tumors, named Noninvasive Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). This pre-malignant tumor is considered to be the putative precursor of invasive carcinomas. However, given that several issues are still unresolved, the application of ancillary tools, based on omics-techniques, may improve the clinical management of these challenging cases. The present paper highlights the proteomic profiles of a series of NIFTPs submitted to Fine Needle Aspirations (FNAs) and analysed by MALDI-imaging in order to confirm the heterogeneous phenotype of nodules included in the present NIFTP terminology and to underline the necessity of more accurate biomarkers that can be used for their characterization. Ethical and economic implications in terms of healthcare costs, operative risks, morbidity, as well as the potential need for lifelong hormone replacement therapy, seem to be significant reasons to approach the characterization of NIFTPs using alternative tools such as MALDI-MSI.
- Published
- 2020