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2. Expression of sarcolectin in the human pituitary gland and amniotic fluid

Author

Ammar Achour, Jean-Pierre M'Bika, Charles Chany, and Wael Khazen

Subjects
Male, medicine.medical_specialty, Pituitary gland, Amniotic fluid, medicine.medical_treatment, Cell, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Biology, Biochemistry, Polymerase Chain Reaction, Cytokeratin, Interferon, Internal medicine, Lectins, medicine, Humans, Aged, DNA Primers, Aged, 80 and over, Messenger RNA, Base Sequence, Growth factor, fungi, General Medicine, Middle Aged, Amniotic Fluid, Molecular biology, Immunohistochemistry, Endocrinology, medicine.anatomical_structure, Pituitary Gland, Female, medicine.drug
Abstract

Sarcolectin (SCL) is a 55 kDa protein cross-reacting with a cytokeratin 7 monomer found in placental blood, sarcomas and various tissues. It blocks the synthesis of interferon-dependent secondary proteins, induces cell DNA activation and sensitizes cells to viral infection. SCL is a potent promoter of tissue growth. In the present report, we demonstrate that SCL is expressed in the human pituitary gland at the mRNA and protein levels. We show also its presence in human amniotic fluid in high titres while interferon titres is weak. These results allow to postulate a potential role of SCL as a growth factor participating in human foetal development.

Published
2010

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