1. Multifunctional Porous Iron Oxide Nanoagents for MRI and Photothermal/Chemo Synergistic Therapy.
- Author
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Hu Y, Hu H, Yan J, Zhang C, Li Y, Wang M, Tan W, Liu J, and Pan Y
- Subjects
- Animals, Antineoplastic Agents administration & dosage, Cell Line, Tumor, Combined Modality Therapy methods, Doxorubicin administration & dosage, Drug Carriers administration & dosage, Drug Carriers therapeutic use, Drug Liberation, Female, Ferric Compounds administration & dosage, Hyperthermia, Induced methods, Magnetic Resonance Imaging, Mammary Neoplasms, Animal diagnostic imaging, Mice, Nanoshells administration & dosage, Nanoshells ultrastructure, Phototherapy methods, Porosity, Antineoplastic Agents therapeutic use, Doxorubicin therapeutic use, Ferric Compounds therapeutic use, Mammary Neoplasms, Animal therapy, Nanoshells therapeutic use, Theranostic Nanomedicine methods
- Abstract
Nanoagents of integrating multiple imaging and therapeutic modalities have attracted tremendous attention for biomedical applications. Herein, we synthesize porous hollow Fe
3 O4 as a theranostic agent for MRI and combined photothermal/chemo cancer therapy. The as-prepared porous iron oxide nanoagents allow for T2 -weighted MR imaging. Interestingly, we demonstrate that the porous structure endows the nanoagents an outstanding photothermal property for cancer cell killing, in comparison with other types of iron oxide nanomaterials. Under the exposure of an NIR laser, the heat produced by porous Fe3 O4 can accelerate the release of the loaded drug (e.g., DOX) to enhance chemotherapeutic efficacy, promoting the ablation of cancer cells with synergistic photothermal/chemotherapy.- Published
- 2018
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