1. Self‐assembly of PEG–PPS polymers and LL‐37 peptide nanomicelles improves the oxidative microenvironment and promotes angiogenesis to facilitate chronic wound healing
- Author
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Rong Shi, Jianxiong Qiao, Quanwu Sun, Biao Hou, Bo Li, Ji Zheng, Zhenzhen Zhang, Zhenxue Peng, Jing Zhou, Bingbing Shen, Jun Deng, and Xuanfen Zhang
- Subjects
angiogenesis ,diabetic wound healing ,inflammatory microenvironment ,LL‐37@PEG–PPS nanomicelles ,Chemical engineering ,TP155-156 ,Biotechnology ,TP248.13-248.65 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Refractory diabetic wounds are associated with high incidence, mortality, and recurrence rates and are a devastating and rapidly growing clinical problem. However, treating these wounds is difficult owing to uncontrolled inflammatory microenvironments and defective angiogenesis in the affected areas, with no established effective treatment to the best of our knowledge. Herein, we optimized a dual functional therapeutic agent based on the assembly of LL‐37 peptides and diblock copolymer poly(ethylene glycol)–poly(propylene sulfide) (PEG–PPS). The incorporation of PEG–PPS enabled responsive or controlled LL‐37 peptide release in the presence of reactive oxygen species (ROS). LL‐37@PEG–PPS nanomicelles not only scavenged excessive ROS to improve the microenvironment for angiogenesis but also released LL‐37 peptides and protected them from degradation, thereby robustly increasing angiogenesis. Diabetic wounds treated with LL‐37@PEG–PPS exhibited accelerated and high‐quality wound healing in vivo. This study shows that LL‐37@PEG–PPS can restore beneficial angiogenesis in the wound microenvironment by continuously providing angiogenesis‐promoting signals. Thus, it may be a promising drug for improving chronic refractory wound healing.
- Published
- 2024
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