1. Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives.
- Author
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Li, Junjun, Liu, Li, Zhang, Jingbo, Qu, Xiang, Kawamura, Takuji, Miyagawa, Shigeru, and Sawa, Yoshiki
- Subjects
CARDIAC regeneration ,INDUCED pluripotent stem cells ,HUMAN embryonic stem cells ,HEART ,TISSUE engineering ,PLURIPOTENT stem cells ,HUMAN stem cells ,TISSUE culture - Abstract
Heart failure (HF) is the leading cause of death worldwide. The most effective HF treatment is heart transplantation, the use of which is restricted by the limited supply of donor hearts. The human pluripotent stem cell (hPSC), including human embryonic stem cell (hESC) and the induced pluripotent stem cells (hiPSC), could be produced in an infinite manner and differentiated into cardiomyocytes (CMs) with high efficiency. The hPSC-CMs have, thus, offered a promising alternative for heart transplant. In this review, we introduce the tissue-engineering technologies for hPSC-CM, including the materials for cell culture and tissue formation, and the delivery means into the heart. The most recent progress in clinical application of hPSC-CMs is also introduced. In addition, the bottleneck limitations and future perspectives for clinical translation are further discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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