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The T/t locus was a major focus of study by mouse geneticists during the 20th century. In the 70s, as the study of cell surface antigens controlling transplantation antigens was taking off, several laboratories hypothesized that alleles of this locus would control cell surface antigens important for embryonic development. One such antigen, the embryonal carcinoma F9 antigen was said to be an example. Other antigens were described on sperm and embryos that were said to be controlled by alleles at the T/t complex. These findings were later found to be false. The history of the findings and their refutation is described. [ABSTRACT FROM AUTHOR]

Focuses on the identification of human pharmacogenetic variants, with reference to the genetics of `specially engineered shotgun loads' in pharmacotherapy. Information on pharmacogenetics; Implications of the `specially engineered shotgun load' paradigm.