1. 50 bp deletion in promoter superoxide dismutase 1 gene and increasing risk of cardiovascular disease in Mashhad stroke and heart atherosclerotic disorder cohort study
- Author
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Parvin Zamani, Habibollah Esmaily, Susan Darroudi, Mohsen Mouhebati, Hamideh Ghazizadeh, Majid Ghayour-Mobarhan, Narges Fereydouni, Gordon A. Ferns, Amir Avan, Zahra Asadi, Fatemeh Sadabadi, Maryam Tayefi, Amir Tajbakhsh, Noushin Akbari Sark, Amir H. Mohammadpour, and Batool Tayefi
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Heart Diseases ,Clinical Biochemistry ,SOD1 ,Blood lipids ,Comorbidity ,Polymorphism, Single Nucleotide ,Risk Assessment ,Biochemistry ,Cohort Studies ,Superoxide dismutase ,03 medical and health sciences ,Superoxide Dismutase-1 ,0302 clinical medicine ,Internal medicine ,Genotype ,Prevalence ,Humans ,Medicine ,Allele ,Genotyping ,biology ,business.industry ,Heterozygote advantage ,Promoter ,General Medicine ,Middle Aged ,Atherosclerosis ,Stroke ,030104 developmental biology ,Endocrinology ,Cardiovascular Diseases ,Case-Control Studies ,030220 oncology & carcinogenesis ,biology.protein ,Molecular Medicine ,Female ,business ,Gene Deletion ,Follow-Up Studies - Abstract
Cardiovascular disease (CVD), one of the main mortality causes worldwide is considered to be affected by general oxidative stress and inadequacy antioxidant system. Superoxide dismutase 1 (SOD1), a cytosolic antioxidant enzyme has a key role in neutralizing the excessive prooxidant by scavenging the super oxide anions. SOD1 polymorphic variants exhibit the altered activity properties. In the current study, we are aimed to investigate the association between the SOD1 polymorphism and CVD prevalence. A 6-years case control follow up study was designed to genotype the 526 participants (311 controls and 215 cases) for studying the 50 bp INS/DEL polymorphism at SOD1 promoter gene and analyze their blood lipid profile and anthropometric characteristics. Among the two possible alleles of the SOD1 gene (Wild [W] and Mutant [M]) the meaningful association was detected between the Mutants' frequency and the prevalence of CVD patients (p-value
- Published
- 2019
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