1. Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis
- Author
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Keiko Fujii, Takuji Tanaka, Kengo Matsunaga, Jun Ushida, Akira Hara, Hideki Mori, Kunihiro Kawabata, and Hiromichi Murai
- Subjects
Coumaric Acids ,Clinical Biochemistry ,medicine.disease_cause ,digestive system ,Biochemistry ,Chemoprevention ,Coffee ,law.invention ,Ferulic acid ,chemistry.chemical_compound ,Chlorogenic acid ,law ,otorhinolaryngologic diseases ,medicine ,Animals ,Anticarcinogenic Agents ,Humans ,Food science ,Coffee bean ,Azoxymethane ,food and beverages ,Oryza ,General Medicine ,digestive system diseases ,chemistry ,Polyphenol ,Molecular Medicine ,Chlorogenic Acid ,Carcinogenesis ,Phytotherapy ,Colorectal Neoplasms ,Azo Compounds ,Aberrant crypt foci - Abstract
Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.
- Published
- 2001