1. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation.
- Author
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Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, and Chuang JH
- Subjects
- Animals, Base Sequence, Conserved Sequence, DNA chemistry, Humans, Internet, Molecular Sequence Data, Software, Computational Biology methods, Databases, Genetic, Gene Expression Regulation, Regulatory Sequences, Nucleic Acid, Zebrafish genetics
- Abstract
There are thousands of strongly conserved non-coding elements (CNEs) in vertebrate genomes, and their functions remain largely unknown. However, without biologically relevant criteria for prioritizing them, selecting a particular CNE sequences to study can be haphazard. To address this problem, we present cneViewer-a database and webtool that systematizes information on conserved non-coding DNA elements in zebrafish. A key feature here is the ability to search for CNEs that may be relevant to tissue-specific gene regulation, based on known developmental expression patterns of nearby genes. cneViewer provides this and other organizing features that significantly facilitate experimental design and CNE analysis.
- Published
- 2008
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