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Measles caused by the virus is highly infectious and sometimes fatal, but it is prevented through vaccination. In Kyrgyzstan, measles cases were initially documented in September 2023, with a notable escalation observed between November and December of the same year. Children aged 3-5 years and 1-2 years exhibited the highest prevalence rates, followed by infants under one year old. Unvaccinated children constituted the majority of cases, with schoolchildren and kindergarten attendees also affected. Surprisingly, a significant proportion of measles cases occurred in vaccinated children, primarily those who received the MMR or Rubella-measles vaccine. Doctors identified 22 recent measles outbreaks and none of the 75 contacts recorded in these outbreaks acquired the disease. Therefore, it is of interest to report an analysis of measles outbreak spike at Jalal-Abad city of Kyrgyzstan in 2023., Competing Interests: The authors declare that they have no conflicts of interest., (© 2024 Biomedical Informatics.)