1. Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents
- Author
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Savani Bartholdy, Owen G. O’Daly, Iain C. Campbell, Tobias Banaschewski, Gareth Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Ulrike Schmidt, Michael Rapp, Eric Artiges, Sophia Schneider, Christine Bach, Tomas Paus, Alexis Barbot, null Gareth Barker, Arun Bokde, Nora Vetter, Anna Cattrell, Patrick Constant, Hans Crombag, Katharina Czech, Jeffrey Dalley, Benjamin Decideur, Tade Spranger, Tamzin Ripley, Nadja Heym, Wolfgang Sommer, Birgit Fuchs, Jürgen Gallinat, Rainer Spanagel, Mehri Kaviani, Bert Heinrichs, null Andreas Heinz, Naresh Subramaniam, Tianye Jia, Albrecht Ihlenfeld, James Ireland, Patricia Conrod, Jennifer Jones, Arno Klaassen, Christophe Lalanne, Dirk Lanzerath, Claire Lawrence, Hervé Lemaitre, Sylvane Desrivieres, Catherine Mallik, null Karl Mann, Adam Mar, Lourdes Martinez-Medina, null Jean-Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Yannick Schwartz, Ruediger Bruehl, Kathrin Müller, Charlotte Nymberg, Mark Lathrop, null Trevor Robbins, Zdenka Pausova, null Jani Pentilla, Francesca Biondo, null Jean-Baptiste Poline, Sabina Millenet, null Michael Smolka, Juliane Fröhner, Maren Struve, null Steve Williams, Thomas Hübner, Semiha Aydin, John Rogers, Alexander Romanowski, Christine Schmäl, Dirk Schmidt, Stephan Ripke, Mercedes Arroyo, Florian Schubert, Yolanda Pena-Oliver, Mira Fauth-Bühler, Xavier Mignon, Claudia Speiser, Tahmine Fadai, null Dai Stephens, Andreas Ströhle, Marie-Laure Paillere, Nicole Strache, David Theobald, Sarah Jurk, Helene Vulser, Ruben Miranda, Juliana Yacubian, Alexander Genauck, Caroline Parchetka, Isabel Gemmeke, Johann Kruschwitz, Katharina Weiß, Jianfeng Feng, Dimitri Papadopoulos, Irina Filippi, Alex Ing, Barbara Ruggeri, Bing Xu, Christine Macare, Congying Chu, Eanna Hanratty, Gabriel Robert, Tao Yu, Veronika Ziesch, and Alicia Stedman
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Adolescent ,Binge eating ,Prefrontal Cortex ,Neuroimaging ,Stop signal ,Audiology ,Gyrus Cinguli ,Feeding and Eating Disorders ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Longitudinal Studies ,Prospective Studies ,Disordered eating ,Prefrontal cortex ,Inhibitory control ,Biological Psychiatry ,Anterior cingulate cortex ,medicine.diagnostic_test ,business.industry ,Functional Neuroimaging ,medicine.disease ,Stop signal task ,Magnetic Resonance Imaging ,Eating disorders ,Inhibition, Psychological ,030104 developmental biology ,medicine.anatomical_structure ,Case-Control Studies ,Cohort ,Female ,medicine.symptom ,Functional magnetic resonance imaging ,business ,030217 neurology & neurosurgery ,Biomarkers ,Psychomotor Performance - Abstract
Background Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. Methods The study used prospective longitudinal data from the European IMAGEN study adolescent cohort. Participants completed baseline assessments (questionnaires and a brain scan [functional magnetic resonance imaging]) at 14 years of age and a follow-up assessment (questionnaires) at 16 years of age. Self-reported binge eating and/or purging were used to indicate presence of DEB. Neural correlates of failed inhibition were assessed using the stop signal task. Participants were categorized as healthy control subjects (reported no DEB at both time points), maintainers (reported DEB at both time points), recoverers (reported DEB at baseline only), and developers (reported DEB at follow-up only). Forty-three individuals per group with complete scanning data were matched on gender, age, puberty, and intelligence (N = 172). Results At baseline, despite similar task performance, incorrectly responding to stop signals (failed inhibitory control) was associated with greater recruitment of the medial prefrontal cortex and anterior cingulate cortex in the developers compared with healthy control subjects and recoverers. Conclusions Greater recruitment of the medial prefrontal and anterior cingulate regions during failed inhibition accords with abnormal evaluation of errors contributing to DEB development. As this precedes symptom onset and is evident despite normal task performance, neural responses during failed inhibition may be a useful biomarker of vulnerability for DEB. This study highlights the potential value of prospective neuroimaging studies for identifying markers of illness before the emergence of behavior changes.
- Published
- 2019
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