1. Sensorimotor gating in healthy adults tested over a 15 year period
- Author
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Brinda K. Rana, Jo Talledo, Neal R. Swerdlow, Savita G. Bhakta, Justin Kei, and Hsun-Hua Chou
- Subjects
Adult ,Male ,Reflex, Startle ,medicine.medical_specialty ,Adolescent ,Period (gene) ,Sensorimotor Gating ,Sensorimotor gating ,Audiology ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Clinical Research ,Reflex ,medicine ,Humans ,Psychology ,Longitudinal Studies ,Pathological ,Brain function ,Prepulse inhibition ,Prepulse Inhibition ,General Neuroscience ,Startle ,Neurosciences ,Healthy subjects ,Experimental Psychology ,030227 psychiatry ,Neuropsychology and Physiological Psychology ,Catechol-O-methyl transferase ,Female ,Cognitive Sciences ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Background Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to study normal and pathological brain function. From 2001 to 2016, we screened healthy subjects (HS) to establish their suitability for tests of drug effects on PPI. Because of the size and systematic characterization of this sample across variables of relevance to PPI, we now report these screening results. Methods Acoustic startle and PPI were assessed in HS to identify those eligible for studies of drug effects on PPI from 2001 to 2016, yielding 457 “eligible” subjects. Results Data confirmed the consistency of PPI across this 15-year period, and supported the role of several variables previously reported to moderate either startle or PPI. Conclusions Startle and PPI are robust physiological measures that are predictably moderated by specific physiological variables in healthy adults. As such, these measures serve as robust markers of neurobiological processes in healthy and patient populations.
- Published
- 2017