1. Investigation of the Radioprotective Efficiency of Condensation Products of Thiol-Containing Hydrazides with Mono- and Disaccharides
- Author
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E. A. Yakunchikova, M. A. Kopanitsa, I. V. Lagoda, I. S. Drachyov, A. Yu. Ershov, A. N. Grebenyuk, A. A. Martynenkov, and L. Yu. Kuleshova
- Subjects
0106 biological sciences ,0301 basic medicine ,chemistry.chemical_classification ,Condensation ,Biology ,010603 evolutionary biology ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,030104 developmental biology ,chemistry ,Thiol ,Monosaccharide ,General Agricultural and Biological Sciences ,Nuclear chemistry - Abstract
In experiments in mice, the radioprotective efficacy of sugar-containing compounds was studied based on the condensation products of thioglycolic (TGH) and thiosalicylic (TSH) hydrazides with a series of natural aldoses: the monosaccharides D-glucose (Glс) and D-galactose (Gal) and the disaccharides D‑lactose (Lac) and D-maltose (Mal). It was shown that the use of Glc-TGH and Mal-TSH preparations increases the survival rate of deadly irradiated animals by 25% when administered 1 h before irradiation and by 40% when administered 24 h before irradiation. It is assumed that the leading role in the radioprotective activity of the drugs is played by the protection of the hematopoietic stem cells of the test animals.
- Published
- 2020
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