1. Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies
- Author
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Adolfo López-Cerdán, Zoraida Andreu, Marta R. Hidalgo, Rubén Grillo-Risco, José Francisco Català-Senent, Irene Soler-Sáez, Almudena Neva-Alejo, Fernando Gordillo, María de la Iglesia-Vayá, and Francisco García-García
- Subjects
Parkinson disease ,Sex differences ,Meta-analysis ,Transcriptomics ,Neurodegeneration ,Medicine ,Physiology ,QP1-981 - Abstract
Highlights Females show a significant increase in the expression of MED31 in the frontal cortex. This gene is involved in lipid metabolism and neural diseases. We found 237 genes having sex-based significantly differential expression in substantia nigra. Functional profiling of these genes reveals a differential sex-related behavior in PD regarding their biological functions, protein-protein interaction networks, and transcription factors activation. There are remarkable sex based differential mechanisms in typical PD hallmarks: inflammation, mitochondrial dysfunction, and oxidative stress. Studies on sex differences in PD are needed to improve more targeted interventions.
- Published
- 2022
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