1. Trimethylene Carbonate and epsilon-Caprolactone Based (co)Polymer Networks
- Author
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Josee A. Plantinga, Zheng Zhang, Jan Feijen, Martin C. Harmsen, Marja J. A. van Luyn, Dirk W. Grijpma, Erhan Bat, Faculty of Science and Technology, Biomaterials Science and Technology, Molecular Nanofabrication, Nanotechnology and Biophysics in Medicine (NANOBIOMED), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), and Vascular Ageing Programme (VAP)
- Subjects
3-TRIMETHYLENE CARBONATE ,POLY(TRIMETHYLENE CARBONATE) ,Polymers and Plastics ,CROSS-LINKING ,Cell Survival ,Polymers ,Polyesters ,POLY(1 ,Bioengineering ,Biomaterials ,Dioxanes ,chemistry.chemical_compound ,Lactones ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Humans ,Lipase ,Polycarbonate ,Pliability ,3-TRIMETHYLENE CARBONATE) ,IR-68966 ,chemistry.chemical_classification ,Aqueous solution ,METIS-254015 ,biology ,IN-VITRO DEGRADATION ,POLY(EPSILON-CAPROLACTONE) ,Polymer ,ALIPHATIC POLYESTERS ,Fibroblasts ,POLY(1,3-TRIMETHYLENE CARBONATE) ,COPOLYMERS ,CYCLIC CARBONATES ,chemistry ,Chemical engineering ,TISSUE ,1,3-TRIMETHYLENE CARBONATE ,visual_art ,Polycaprolactone ,biology.protein ,visual_art.visual_art_medium ,Trimethylene carbonate ,Caprolactone - Abstract
High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytotoxicity, surface properties, degradation behavior, and mechanical and thermal properties of these (co)polymers and networks were investigated. Upon incubation with cell culture medium containing extracts of (co)polymers and networks, human foreskin fibroblasts remained viable. For all (co)polymers and networks, cell viabilities were determined to be higher than 94%. The formed networks were flexible, with elastic moduli ranging from 2.7 to 5.8 MPa. Moreover, these form-stable networks were creep resistant under dynamic conditions. The permanent deformation after 2 h relaxation was as low as 1% after elongating to 50% strain for 20 times. The in vitro enzymatic erosion behavior of these hydrophobic (co)polymers and networks was investigated using aqueous lipase solutions. The erosion rates in lipase solution could be tuned linearly from 0.8 to 45 Mg/(cm(2) x day) by varying the TMC to CL ratio and the irradiation dose. The copolymers and networks degraded essentially by a surface erosion mechanism.
- Published
- 2008