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Your search keyword '"Yin, Da-Chuan"' showing total 6 results
Start Over Author "Yin, Da-Chuan" Journal biomacromolecules
6 results on '"Yin, Da-Chuan"'

4. Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive Manufacturing

Author

Deng, Xudong, Attalla, Rana, Sadowski, Lukas P., Chen, Mengsu, Majcher, Michael J., Urosev, Ivan, Yin, Da-Chuan, Selvaganapathy, P. Ravi, Filipe, Carlos D. M., and Hoare, Todd

Abstract

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic cross-linking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within 1 min after cutting or shear under both neutral and acidic pH conditions. Incorporation of this hydrogel in an interpenetrating calcium-alginate network results in an interfacially stiffer but still rapidly self-adhesive hydrogel that can be assembled into hollow perfusion channels by simple contact additive manufacturing within minutes. Such channels withstand fluid perfusion while retaining their dimensions and support endothelial cell growth and proliferation, providing a simple and modular route to produce customized cell scaffolds.

Published
2024
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6. Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive Manufacturing.

Author

Deng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin DC, Selvaganapathy PR, Filipe CDM, and Hoare T

Subjects
Boronic Acids chemistry, Cross-Linking Reagents chemistry, Epithelial Cells cytology, Human Umbilical Vein Endothelial Cells, Humans, Hyaluronic Acid chemistry, Hydrogen-Ion Concentration, Polyvinyl Alcohol chemistry, Adhesives chemistry, Hydrogels chemistry, Tissue Engineering methods, Tissue Scaffolds
Abstract

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic cross-linking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within 1 min after cutting or shear under both neutral and acidic pH conditions. Incorporation of this hydrogel in an interpenetrating calcium-alginate network results in an interfacially stiffer but still rapidly self-adhesive hydrogel that can be assembled into hollow perfusion channels by simple contact additive manufacturing within minutes. Such channels withstand fluid perfusion while retaining their dimensions and support endothelial cell growth and proliferation, providing a simple and modular route to produce customized cell scaffolds.

Published
2018
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