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Context: Sepsis is now the leading cause of death in the noncardiovascular intensive care unit (ICU). Objective: To investigate whether polymorphisms in IL21 gene contribute to sepsis susceptibility. Materials and methods: Three single-nucleotide polymorphisms of IL21 (rs907715, rs2055979, rs12508721) were genotyped by TaqMan assay in patients with sepsis and control subjects. Results: Polymorphisms rs2055979 and rs12508721 in IL21 were more frequent in sepsis patients compared to general population. But allele frequency of rs907715 was not significantly different between sepsis patients and control subjects. Conclusion: Polymorphisms in IL21 may be associated with sepsis risk. [ABSTRACT FROM AUTHOR]

Context: Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis. Objective: To investigate whether polymorphisms inIL27contribute to renal cell carcinoma (RCC) risk. Materials and methods: These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109:p = 0.006, OR = 1.364, 95%CI = 1.095–1.700; rs17855750:p = 0.001, OR = 1.768, 95%CI = 1.245–2.511). Conclusion: The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis. [ABSTRACT FROM PUBLISHER]

Context: AXIN1 is a central component of Wnt signalling pathway which is essential for embryonic development. Objective: To investigate whether polymorphisms of AXIN1 contribute to ASD susceptibility. Materials and methods: Three tag SNPs (rs12921862, rs370681 and rs1805105) in AXIN1 were genotyped in 208 ASD patients and 302 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a Chinese population. Results: Significantly increased ASD risk was observed to be associated with the A allele of rs12921862 ( p < 0.0001, OR = 3.096, 95% CI = 2.037-4.717). Increased ASD risk was observed to be associated with rs370681 in a codominant ( p = 0.043, OR = 1.52, 95% CI = 1.04-2.22) and overdominant model ( p = 0.016, OR = 1.57, 95% CI = 1.08-2.27). Conclusion: rs12921862 and rs370681 may contribute to ASD susceptibility. [ABSTRACT FROM AUTHOR]