1. The impact of mitochondria-related
- Author
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Ieva, Golubickaite, Rasa, Ugenskiene, Erika, Korobeinikova, Jurgita, Gudaitiene, Domas, Vaitiekus, Lina, Poskiene, and Elona, Juozaityte
- Subjects
Adult ,Genotype ,Breast Neoplasms ,Kaplan-Meier Estimate ,Middle Aged ,Polymorphism, Single Nucleotide ,DNA Polymerase gamma ,Mitochondria ,DNA-Binding Proteins ,Mitochondrial Proteins ,Logistic Models ,Gene Frequency ,Humans ,Female ,Genetic Predisposition to Disease ,Neoplasm Recurrence, Local ,Alleles ,Aged ,Transcription Factors - Abstract
Breast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration. This study aimed to analyse 10 single nucleotide variants inA total of 234 breast cancer patients were included in this study. Variations were determined with Real-Time PCR using TaqManWe found that patients withOur data suggest that variations in
- Published
- 2021