1. Plasma carbonyls do not correlate with lung function or computed tomography measures of lung density in older smokers.
- Author
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Mesia-Vela S, Yeh CC, Austin JH, Dounel M, Powell CA, Reeves A, Santella RM, Stevenson L, Yankelevitz D, and Barr RG
- Subjects
- Age Factors, Aged, Biomarkers blood, Enzyme-Linked Immunosorbent Assay, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Protein Carbonylation, Pulmonary Disease, Chronic Obstructive blood, Pulmonary Disease, Chronic Obstructive pathology, Pulmonary Disease, Chronic Obstructive physiopathology, Pulmonary Emphysema blood, Pulmonary Emphysema pathology, Pulmonary Emphysema physiopathology, Respiratory Function Tests, Smoking pathology, Smoking physiopathology, Vital Capacity, Blood Proteins metabolism, Lung pathology, Lung physiopathology, Smoking blood, Tomography, X-Ray Computed
- Abstract
Oxidative stress and inflammation are hallmarks of chronic obstructive pulmonary disease (COPD). A critical byproduct of oxidative damage is the introduction of carbonyl groups into amino acid residues. We hypothesize that plasma carbonyl content is inversely correlated with lung function and computed tomography (CT) measures of lung density among smokers and is elevated in COPD. Carbonyl was measured in plasma of participants aged 60 years and older by ELISA. Generalized linear and additive models were used to adjust for potential confounders. Among 541 participants (52% male, mean age 67 years, 41% current smokers), mean plasma carbonyl content was 17.9+/-2.9 nmol ml(-1) and mean forced expiratory volume in one second (FEV(1)) was 80.7+/-20.9% of predicted. Plasma carbonyl content was inversely associated with FEV(1), but this relationship was largely explained by age. Multivariate analyses ruled out clinically meaningful associations of plasma carbonyl content with FEV(1), FEV(1)/FVC (forced vital capacity) ratio, severity of airflow obstruction, and CT lung density. Plasma carbonyl content is a poor biomarker of oxidative stress in COPD and emphysema.
- Published
- 2008
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