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3 results on '"Fanchon Bourasset"'

1. Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI

Author

Elias Fattal, Céline Giraudeau, Claire Gueutin, Nicolas Tsapis, Christine Vauthier, Fanchon Bourasset, Julien Valette, Sandrine Zanna, and Odile Diou

Subjects
Materials science, Scanning electron microscope, Biophysics, Analytical chemistry, Contrast Media, Mice, Nude, Bioengineering, Nanocapsules, Biomaterials, Mice, chemistry.chemical_compound, Dynamic light scattering, Bromide, Cell Line, Tumor, Zeta potential, Animals, Particle Size, Fluorocarbons, technology, industry, and agriculture, Magnetic Resonance Imaging, Hydrocarbons, Brominated, PLGA, chemistry, Mechanics of Materials, Transmission electron microscopy, Colonic Neoplasms, Ceramics and Composites, PEGylation, Female, Nuclear chemistry
Abstract

PLGA-PEG nanocapsules containing a liquid core of perfluorooctyl bromide were synthesized by an emulsion-evaporation process and designed as contrast agents for 19 F MRI. Physico-chemical properties of plain and PEGylated nanocapsules were compared. The encapsulation efficiency of PFOB, estimated by 19 F NMR spectroscopy, is enhanced when using PLGA-PEG instead of PLGA. PLGA-PEG nanocapsule diameter, measured by Dynamic Light Scattering is around 120 nm, in agreement with Transmission Electron microscopy (TEM) observations. TEM and Scanning Electron Microscopy (SEM) reveal that spherical core–shell morphology is preserved. PEGylation is further confirmed by Zeta potential measurements and X-ray Photoelectron Spectroscopy. In vitro , stealthiness of the PEGylated nanocapsules is evidenced by weak complement activation. Accumulation kinetics in the liver and the spleen was performed by 19 F MRI in mice, during the first 90 min after intravenous injection. In the liver, plain nanocapsules accumulate faster than their PEGylated counterparts. We observe PEGylated nanocapsule accumulation in CT26 xenograft tumor 7 h after administration to mice, whereas plain nanocapsules remain undetectable, using 19 F MRI. Our results validate the use of diblock copolymers for PEGylation to increase the residence time of nanocapsules in the blood stream and to reach tumors by the Enhanced Permeation and Retention (EPR) effect.

Published
2012

2. The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

Author

Fathi Moussa, Leila Njim, Fanchon Bourasset, Manef Abderrabba, Abdelhamid Kerkeni, Tarek Baati, Henri Szwarc, Najla Gharbi, BRANDEL, Clément, Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychopharmacologie des addictions. Vulnérabilité et variabilité expérimentale et clinique (NAVVEC - UM 81 (UMR 8206/ U705)), Université Paris Diderot - Paris 7 (UPD7)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Institut National de Recherches et d'Analyses Physicochimiques Tunisie, Laboratoire de Physicochimie des Matériaux - IPEST(La Marsa, Tunisia), Institut préparatoire aux études scientifiques et techniques [La Marsa] (IPEST), Laboratoire de Biophysique [Monastir], Faculté de Médecine de Monastir [Tunisie], Lip(Sys)2 , LETIAM (formerly included in EA4041 Groupe de Chimie Analytique de Paris-Sud), Univ. Paris-Sud, Université Paris-Saclay, Institut Universitaire de Technologie d'Orsay (IUT d'Orsay), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Diderot - Paris 7 (UPD7), and Laboratoire de biophysique

Subjects
[CHIM.INOR] Chemical Sciences/Inorganic chemistry, Male, Aging, Materials science, Biophysics, Administration, Oral, Bioengineering, 02 engineering and technology, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, [SPI.MAT] Engineering Sciences [physics]/Materials, Pharmacology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, Biomaterials, Pharmacokinetics, Oral administration, In vivo, [CHIM.CRIS]Chemical Sciences/Cristallography, medicine, Animals, Plant Oils, [CHIM.CRIS] Chemical Sciences/Cristallography, Rats, Wistar, Olive Oil, Chronic toxicity, ComputingMilieux_MISCELLANEOUS, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 021001 nanoscience & nanotechnology, Rats, 3. Good health, 0104 chemical sciences, Oxidative Stress, Mechanics of Materials, Ageing, Toxicity, Ceramics and Composites, Fullerenes, 0210 nano-technology, Oxidative stress, Olive oil
Abstract

Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C(60) and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C(60) dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C(60) is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing.

Published
2012

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