1. Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering
- Author
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Harry R. Allcock, Syam P. Nukavarapu, William A. Kanner, Sangamesh G. Kumbar, Meng Deng, Xudong Li, Arlin L. Weikel, Nicholas R. Krogman, Tao Jiang, Cato T. Laurencin, and Lakshmi S. Nair
- Subjects
Male ,Materials science ,Biocompatibility ,Polymers ,Polyesters ,Biophysics ,Bioengineering ,Miscibility ,Article ,Rats, Sprague-Dawley ,Biomaterials ,Hydrolysis ,Organophosphorus Compounds ,Differential scanning calorimetry ,Polylactic Acid-Polyglycolic Acid Copolymer ,Materials Testing ,Polymer chemistry ,Animals ,Polyphosphazene ,Lactic Acid ,Fourier transform infrared spectroscopy ,Cells, Cultured ,Cell Proliferation ,chemistry.chemical_classification ,Osteoblasts ,Tissue Engineering ,Tissue Scaffolds ,technology, industry, and agriculture ,Dipeptides ,Polymer ,Glycolates ,Rats ,Polyester ,chemistry ,Mechanics of Materials ,Bone Substitutes ,Ceramics and Composites ,Polyglycolic Acid ,Nuclear chemistry - Abstract
Polyphosphazene-polyester blends are attractive materials for bone tissue engineering applications due to their controllable degradation pattern with non-toxic and neutral pH degradation products. In our ongoing quest for an ideal completely miscible polyphosphazene-polyester blend system, we report synthesis and characterization of a mixed-substituent biodegradable polyphosphazene poly[(glycine ethyl glycinato)(1)(phenyl phenoxy)(1)phosphazene] (PNGEG/PhPh) and its blends with a polyester. Two dipeptide-based blends namely 25:75 (Matrix1) and 50:50 (Matrix2) were produced at two different weight ratios of PNGEG/PhPh to poly(lactic acid-glycolic acid) (PLAGA). Blend miscibility was confirmed by differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscopy. Both blends resulted in higher tensile modulus and strength than the polyester. The blends showed a degradation rate in the order of Matrix2
- Published
- 2010
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