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2 results on '"liver tissue engineering"'

1. Microporous membrane-based liver tissue engineering for the reconstruction of three-dimensional functional liver tissues in vitro.

Author

Kasuya, Junichi and Tanishita, Kazuo

Subjects
*LIVER, *LIVER cells, *CELL culture, *TISSUE engineering, *EXTRACELLULAR matrix
Abstract

To meet the increasing demand for liver tissue engineering, various three-dimensional (3D) liver cell culture techniques have been developed. Nevertheless, conventional liver cell culture techniques involving the suspending cells in extracellular matrix (ECM) components and the seeding of cells into 3D biodegradable scaffolds have an intrinsic shortcoming, low cell-scaffold ratios. We have developed a microporous membrane-based liver cell culture technique. Cell behaviors and tissue organization can be controlled by membrane geometry, and cell-dense thick tissues can be reconstructed by layering cells cultured on biodegradable microporous membranes. Applications extend from liver parenchymal cell monoculture to multi-cell type cultures for the reconstruction of 3D functional liver tissue. This review focuses on the expanding role for microporous membranes in liver tissue engineering, primarily from our research. [ABSTRACT FROM AUTHOR]

Published
2012
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2. Microporous membrane-based liver tissue engineering for the reconstruction of three-dimensional functional liver tissues in vitro

Author

Junichi Kasuya and Kazuo Tanishita

Subjects
microporous membrane, Pathology, medicine.medical_specialty, Materials science, liver tissue engineering, Special Focus Review, Cell, Biomedical Engineering, Cell Culture Techniques, Medicine (miscellaneous), Biocompatible Materials, Biomaterials, Extracellular matrix, Sinusoid, Imaging, Three-Dimensional, bile duct, Parenchyma, medicine, hepatocyte, Humans, Regeneration, Tissue Engineering, Tissue Scaffolds, Liver cell, Liver Diseases, PLGA, General Medicine, Microporous material, Liver, Artificial, Extracellular Matrix, medicine.anatomical_structure, Membrane, Biodegradation, Environmental, Liver, Hepatocyte, Biophysics, Hepatocytes, Bile Ducts, Porosity, Liver Failure, 3D, sinusoid
Abstract

To meet the increasing demand for liver tissue engineering, various three-dimensional (3D) liver cell culture techniques have been developed. Nevertheless, conventional liver cell culture techniques involving the suspending cells in extracellular matrix (ECM) components and the seeding of cells into 3D biodegradable scaffolds have an intrinsic shortcoming, low cell-scaffold ratios. We have developed a microporous membrane-based liver cell culture technique. Cell behaviors and tissue organization can be controlled by membrane geometry, and cell-dense thick tissues can be reconstructed by layering cells cultured on biodegradable microporous membranes. Applications extend from liver parenchymal cell monoculture to multi-cell type cultures for the reconstruction of 3D functional liver tissue. This review focuses on the expanding role for microporous membranes in liver tissue engineering, primarily from our research.

Published
2013

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