1. Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury.
- Author
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Chen, Gunng-Shinng, Huang, Kuo-Feng, Huang, Chien-Chu, and Wang, Jia-Yi
- Subjects
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PULMONARY edema , *ANIMAL experimentation , *BRAIN injuries , *STATISTICAL correlation , *GENE expression , *LUNG injuries , *PROTEINS , *RATS , *RESEARCH funding , *RNA , *ACUTE diseases , *DATA analysis software , *DESCRIPTIVE statistics , *KRUSKAL-Wallis Test , *ONE-way analysis of variance , *PREVENTION ,THERAPEUTIC use of plant extracts - Abstract
Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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