1. Receptor Binding Domain Based HIV Vaccines.
- Author
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Liu, Huan, Bi, Wenwen, Wang, Qian, Lu, Lu, and Jiang, Shibo
- Subjects
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AIDS vaccines , *CELL receptors , *HIV , *IMMUNITY , *IMMUNOGLOBULINS , *GENETIC mutation , *PROTEINS , *T cells , *CD4 antigen , *DRUG development , *MEMBRANE glycoproteins - Abstract
This paper analyzes the main trend of the development of acquired immunodeficiency syndrome (AIDS) vaccines in recent years. Designing an HIV-1 vaccine that provides robust protection from HIV-1 infection remains a challenge despite many years of effort. Therefore, we describe the receptor binding domain of gp120 as a target for developing AIDS vaccines. And we recommend some measures that could induce efficiently and produce cross-reactive neutralizing antibodies with high binding affinity. Those measures may offer a new way of the research and development of the potent and broad AIDS vaccines. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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