1. The Promotional Effect of Hollow MnO 2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis.
- Author
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Hu Q, Zhang S, Zhu J, Yin L, Liu S, Huang X, and Ke G
- Subjects
- Cell Line, Tumor, Emulsions, Female, Humans, Apoptosis drug effects, Brucea chemistry, Cell Proliferation drug effects, Endometrial Neoplasms drug therapy, Endometrial Neoplasms metabolism, Endometrial Neoplasms pathology, Manganese Compounds chemistry, Manganese Compounds pharmacology, Oxides chemistry, Oxides pharmacology, Plant Oils chemistry, Plant Oils pharmacology
- Abstract
Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO
2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H-MnO2 -PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug-delivery vector H-MnO2 -PEG by chemical synthesis and found that H-MnO2 -PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H-MnO2 -PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H-MnO2 -PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H-MnO2 -PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer., Competing Interests: The authors declare no conflict of interest., (Copyright © 2021 Qin Hu et al.)- Published
- 2021
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