1. X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography
- Author
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Qinrui Hu, Huika Xia, Lvzhen Huang, Tian-Qi Li, Xiao-Li Chen, and Xiaoxin Li
- Subjects
Male ,medicine.medical_specialty ,Visual acuity ,Article Subject ,genetic structures ,Retinoschisis ,lcsh:Medicine ,Fundus (eye) ,Retina ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Optical coherence tomography ,Foveal ,Ophthalmology ,Humans ,Medicine ,Child ,Retrospective Studies ,General Immunology and Microbiology ,medicine.diagnostic_test ,Choroid ,business.industry ,lcsh:R ,Retinal ,General Medicine ,Anatomy ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,chemistry ,Child, Preschool ,Clinical Study ,030221 ophthalmology & optometry ,X-linked retinoschisis ,sense organs ,medicine.symptom ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose.To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT).Design.Retrospective, observational study.Methods.Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016. Each eye was measured by SD-OCT using the same clinical protocol. A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed.Results.Six patients demonstrated retinoschisis (12 eyes) and typical foveal cyst-like cavities (10 eyes) on SD-OCT images with a mean logMAR VA of 0.48. The median age was 7.5 years at the initial visit. Their foveal retinal thickness (516.9 μm) and choroid thickness (351.4 μm) decreased at a rate of 38.1 and 7.5 μm, respectively, at the 10.5-month follow-up visit; however, there were no significant differences (P=0.622andP=0.406, resp.). There was no significant correlation between VA, the foveal retinal thickness, and subfoveal choroid thickness.Conclusions.SD-OCT images for XLRS patients during the juvenile period revealed no significant changes in the fundus structure, including the foveal retinal thickness and choroid thickness within one-year follow-up. There was a lack of correlation between VA, foveal retinal thickness, and subfoveal choroid thickness.
- Published
- 2017