1. MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1.
- Author
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Yang, Jing, Sheng, Yuan-Yuan, Wei, Jin-Wang, Gao, Xiao-Mei, Zhu, Ying, Jia, Hu-Liang, Dong, Qiong-Zhu, and Qin, Lun-Xiu
- Subjects
CELL proliferation ,BIOMARKERS ,BIOLOGICAL models ,CANCER invasiveness ,CELL adhesion molecules ,GENE expression ,HEPATOCELLULAR carcinoma ,METASTASIS ,MICE ,MULTIVARIATE analysis ,IN vitro studies ,IN vivo studies ,PROGNOSIS - Abstract
MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in
in vitro , as well asin vivo , tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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