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Your search keyword '"Yang, Dong"' showing total 16 results
Start Over Author "Yang, Dong" Journal biomed research international Publisher hindawi limited
16 results on '"Yang, Dong"'

5. Genome Assembly and Analyses of the Macrofungus Macrocybe gigantea

Author

Xiao Dong, Yesheng Zhang, Zhe Zhang, Qiuju Xia, Yang Dong, Shiming Li, Jun Sheng, Jian Wang, Ling Kui, and Yangzi Wang

Subjects
0301 basic medicine, Macrocybe gigantea, Comparative genomics, Article Subject, General Immunology and Microbiology, biology, 030106 microbiology, Tricholoma, Gigantea, General Medicine, biology.organism_classification, Genome, General Biochemistry, Genetics and Molecular Biology, Macrocybe, White (mutation), 03 medical and health sciences, 030104 developmental biology, Genus, Botany, Medicine
Abstract

Macrocybe gigantea (M. gigantea) is a macrofungus genus that contains a big number of fairly fleshy gilled mushrooms with white spores. This macrofungus produces diverse bioactive compounds, antioxidants, and water-soluble polysaccharides. However, the genomic resources of this species remain unknown. Here, we assembled the genome of M. gigantea (41.23 Mb) into 336 scaffolds with a N50 size of 374,455 bp and compared it with the genomes of eleven other macrofungi. Comparative genomics study confirmed that M. gigantea belonged to the Macrocybe genus, a stand-alone genus different from the Tricholoma genus. In addition, we found that glycosyl hydrolase family 28 (GH28) in M. gigantea shared conserved motifs that were significantly different from their counterparts in Tricholoma. The genomic resource uncovered by this study will enhance our understanding of fungi biology, especially the differences in their growth rates and energy metabolism.

Published
2021

9. MicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone

Author

Shu Qin, Sang Shang, Zhichang Zhang, Yang Dong, and Changwei Li

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Article Subject, Osteoclasts, lcsh:Medicine, Bone Neoplasms, General Biochemistry, Genetics and Molecular Biology, Bone resorption, 03 medical and health sciences, Mice, 0302 clinical medicine, Osteoclast, Internal medicine, microRNA, medicine, Animals, Humans, RNA, Neoplasm, Receptor, Aged, Giant Cell Tumor of Bone, General Immunology and Microbiology, biology, Chemistry, Activator (genetics), RANK Ligand, lcsh:R, General Medicine, Middle Aged, medicine.disease, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Giant cell, RANKL, 030220 oncology & carcinogenesis, biology.protein, Female, Giant-cell tumor of bone, Research Article
Abstract

Giant cell tumor (GCT) of bone is an aggressive skeletal tumor characterized by localized bone resorption. MicroRNA-16-5p (miR-16-5p) has been reported to be downregulated in lesions of patients with GCT, but little is known about its role in GCT. To explore the underlying function of miR-16-5p in GCT, we first detected its expression in patients with GCT. The results showed that osteoclast formation increased, whereas miR-16-5p expression considerably decreased with the severity of bone destruction. Furthermore, we found that miR-16-5p expression considerably decreased with the progression of receptor activator of nuclear factor-κB ligand- (RANKL-) induced osteoclastogenesis. Functionally, miR-16-5p mimics significantly reduced RANKL-induced osteoclast formation. However, treatment with an inhibitor of miR-16-5p significantly promoted osteoclastogenesis. These findings reveal that miR-16-5p inhibits osteoclastogenesis and that it may represent a therapeutic target for giant cell tumor of bone.

Published
2017

15. Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Author

Li, Dong, Hao, Shu-Hong, Sun, Yan, Hu, Chun-Mei, Ma, Zhi-Hua, Wang, Zhi Ming, Liu, Jie, Liu, Hong Bo, Ye, Ming, Zhang, Yu Fei, Yang, Dong Sheng, and Shi, Guang

Subjects
SALIVARY gland tumors, MOUTH tumors, TONGUE tumors, CANCER genetics, CONFIDENCE intervals, GINGIVAL neoplasms, GENES, GENETIC polymorphisms, MEDLINE, META-analysis, NONSTEROIDAL anti-inflammatory agents, ONLINE information services, REGRESSION analysis, SYSTEMATIC reviews, CYCLOOXYGENASE 2, RELATIVE medical risk, DATA analysis software, DESCRIPTIVE statistics, GENETICS, TUMOR risk factors, DISEASE risk factors
Abstract

Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. Conclusion. Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation. [ABSTRACT FROM AUTHOR]

Published
2015
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