1. Pentraxin-3 Predicts Long-Term Cardiac Events in Patients with Chronic Heart Failure
- Author
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Chunming Wang, Junbo Ge, Wei Gao, Haibo Liu, Guozhong Chen, Kang Yao, Wangjun Yu, Xiaofang Guo, and Jie Yuan
- Subjects
Male ,China ,medicine.medical_specialty ,Article Subject ,lcsh:Medicine ,Risk Assessment ,Sensitivity and Specificity ,General Biochemistry, Genetics and Molecular Biology ,Internal medicine ,medicine ,Humans ,Risk factor ,Survival rate ,Serum amyloid P component ,Aged ,Heart Failure ,General Immunology and Microbiology ,biology ,Proportional hazards model ,business.industry ,Incidence ,Incidence (epidemiology) ,lcsh:R ,Hazard ratio ,C-reactive protein ,Reproducibility of Results ,General Medicine ,Prognosis ,medicine.disease ,Survival Rate ,Serum Amyloid P-Component ,C-Reactive Protein ,Death, Sudden, Cardiac ,Heart failure ,Chronic Disease ,biology.protein ,Cardiology ,Female ,business ,Biomarkers ,Research Article - Abstract
The aim of this study was to investigate the long-term prognostic value of pentraxin-3 (PTX3) in patients with chronic heart failure (CHF). 377 patients were prospectively followed up for 3 years to determine cardiac events including cardiac death or rehospitalization for worsening heart failure. The plasma PTX3 levels were significantly higher in CHF patients than in healthy subjects (p<0.001), and they increased with advancing New York Heart Association (NYHA) Functional Classification (p<0.001). Plasma PTX3 levels in CHF patients with cardiac events were significantly higher than in event-free patients (p<0.001). We determined the normal upper limit of plasma PTX3 levels from the mean + 2 SD value of 64 control subjects (3.64 ng/mL). A Kaplan-Meier analysis revealed that patients with increased PTX3 (≥3.64 ng/mL) were at a higher risk for cardiac events than those without increased PTX3 (p<0.01). A multifactorial Cox proportional hazards model showed that increased PTX3 (≥3.64 ngImL) was an independent risk factor for cardiac events in CHF patients (hazard ratio (HR) = 4.224,p<0.01; 95% CI: 1.130–15.783). Plasma PTX3 levels are a long-term independent predictor of prognosis in patients with CHF.
- Published
- 2015