1. Use of Autologous Serum Eye Drops with Contact Lenses in the Treatment of Chemical Burn-Induced Bilateral Corneal Persistent Epithelial Defects.
- Author
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Chen, Yan-Ming, Wang, Wei-Yu, Lin, Yen-Chun, Tsai, Shih-Hao, and Lou, Yun-Ting
- Subjects
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SILICONES , *PATIENT aftercare , *PLATELET-rich plasma , *OPTOMETRY , *CHEMICAL burns , *ACQUISITION of data methodology , *INJECTIONS , *SERUM , *CORNEA diseases , *CONTACT lenses , *RETROSPECTIVE studies , *OPHTHALMIC drugs , *EPITHELIUM , *CONJUNCTIVA , *PHARMACEUTICAL gels , *MEDICAL records , *VISUAL acuity , *CUTANEOUS therapeutics , *DISEASE complications - Abstract
Objective. We aim to evaluate the clinical effect of combined topical 20% autologous serum eye drops (ASEs) along with silicone–hydrogel soft contact lenses (SCLs) in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects (PEDs) and to review the literature of related studies. Methods. From January 1, 2017, to December 31, 2019, we conducted a retrospective chart review of 8 patients with chemical burn-induced bilateral corneal PEDs who were unsuccessfully treated with conventional medical therapy and were then treated with combined topical 20% (v/v) ASEs and silicone–hydrogel CLs. The clinical effects and effectiveness of the combined treatment were evaluated. Results. The bilateral corneal PEDs healed in all sixteen eyes of the eight patients within 2 weeks. The patients did not report any discomfort associated with the combined treatment. Improved ocular comfort/visual acuity and decreased conjunctival injection correlated with healing. No recurrent corneal epithelial breakdown was noted during the 3-month posttreatment follow-up. Conclusions. The combined treatment of silicone–hydrogel CLs and ASEs can help to stabilize the ocular surface and successfully treat chemical burn-induced bilateral corneal PEDs. It may be considered as an alternative treatment method for patients with bilateral chemical burn-induced corneal PEDs with potential corneal melting. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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