1. Comparison of Ramosetron with Palonosetron for Prevention of Postoperative Nausea and Vomiting in Patients Receiving Opioid-Based Intravenous Patient-Controlled Analgesia after Gynecological Laparoscopy.
- Author
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Ahn, Eun Jin, Choi, Geun Joo, Kang, Hyun, Baek, Chong Wha, Jung, Yong Hun, and Woo, Young Cheol
- Subjects
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THERAPEUTIC use of narcotics , *ANALGESICS , *ANTIEMETICS , *ACADEMIC medical centers , *CHI-squared test , *COMPARATIVE studies , *FISHER exact test , *GYNECOLOGIC surgery , *INTRAVENOUS therapy , *LAPAROSCOPY , *PATIENT-controlled analgesia , *POSTOPERATIVE care , *PROBABILITY theory , *RESEARCH funding , *T-test (Statistics) , *LOGISTIC regression analysis , *DATA analysis , *PAIN measurement , *VISUAL analog scale , *DISEASE incidence , *RETROSPECTIVE studies , *SEVERITY of illness index , *DATA analysis software , *ELECTRONIC health records , *DESCRIPTIVE statistics , *THERAPEUTICS ,PREVENTION of surgical complications - Abstract
We aimed to compare the effects of ramosetron and palonosetron in the prevention of postoperative nausea and vomiting (PONV) in patients that received opioid-based intravenous patient-controlled analgesia (IV-PCA) after gynecological laparoscopy. We reviewed the electronic medical records of 755 adults. Patients were classified into two groups, ramosetron (group R, n=589) versus palonosetron (group P, n=166). Based on their confounding factors, 152 subjects in each group were selected after the implementation of propensity score matching. The overall incidence of PONV at postoperative day (POD) 0 was lower in group R compared to group P (26.9% versus 36.8%; P=0.043). The severity of nausea was lower in group R than in group P on postoperative day (POD) 0 (P=0.012). Also, the complete responder proportion of patients was significantly higher in group R compared to that in group P on POD 0 (P=0.043). In conclusion, ramosetron showed a greater efficacy in the prevention of postoperative nausea at POD 0 compared to palonosetron in patients after gynecological laparoscopy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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