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Your search keyword '"Jung, Ui-Won' showing total 6 results
Start Over Author "Jung, Ui-Won Journal biomed research international
6 results on '"Jung, Ui-Won'

5. Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2

Author

Ui Won Jung, Jae Kook Cha, Daniel S. Thoma, Yoo Kyung Sun, Jung Seok Lee, Seong-Ho Choi, So Ra Yoon, University of Zurich, and Jung, Ui-Won

Subjects
Bone Regeneration, Article Subject, medicine.medical_treatment, Peri, Bone Morphogenetic Protein 2, lcsh:Medicine, 610 Medicine & health, 02 engineering and technology, Dehiscence, Bone morphogenetic protein, General Biochemistry, Genetics and Molecular Biology, law.invention, 10068 Clinic of Reconstructive Dentistry, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta, 1300 General Biochemistry, Genetics and Molecular Biology, law, 2400 General Immunology and Microbiology, medicine, Animals, Humans, Bone regeneration, Saline, Dental Implants, General Immunology and Microbiology, Chemistry, business.industry, lcsh:R, Collagen membrane, 030206 dentistry, General Medicine, 021001 nanoscience & nanotechnology, Recombinant Proteins, Recombinant DNA, Collagen, Implant, 0210 nano-technology, Nuclear medicine, business, Research Article
Abstract

This study is designed to determine the effect of collagen membrane (CM) soaked with bone morphogenetic protein-2 (rhBMP-2) for the treatment of peri-implant dehiscence defects. Material and Methods. Three treatment groups were allocated at each defect in 5 dogs: (i) collagenated synthetic bone (OC) and CM soaked with rhBMP-2 (BMP group), (ii) OC and CM soaked with saline (nonBMP group), and (iii) no further treatment (control group). Titanium pins were used to stabilize the membranes in two dogs. Radiographic and histomorphometric analyses were performed 4 weeks later. Results. The median augmented volumes were 4.27 mm3, 6.24 mm3, and 2.75 mm3 in the BMP, nonBMP, and control groups, respectively; the corresponding median first bone-to-implant contact (fBIC) distances were 3.25 mm, 3.08 mm, and 2.56 mm (P>0.05). The placement of pins (with the BMP and nonBMP groups pooled) significantly improved bone regeneration: the augmented volumes were 17.60 mm3 with pins and 3.68 mm3 without pins (P=0.024), with corresponding fBIC distances of 2.25 mm and 3.31 mm, respectively (P<0.001). Conclusions. The addition of rhBMP-2 to CM failed to improve bone regeneration of peri-implant dehiscence defects compared to using an unsoaked CM after 4 weeks. However, the stabilization of CMs using pins positively influenced the outcomes.

Published
2018

6. Effect of Hypoxia-Inducible Factor 1 α on Early Healing in Extraction Sockets.

Author

Lim HC, Thoma DS, Jeon M, Song JS, Lee SK, and Jung UW

Subjects
Animals, Bone Substitutes, Cattle, Collagen, Dogs, Hypoxia, Male, Tooth Extraction, Hypoxia-Inducible Factor 1, alpha Subunit physiology, Tooth Socket, X-Ray Microtomography
Abstract

The aim of the present study was to investigate the effect of hypoxia-inducible factor 1 α (HIF1A) on the early healing (4 weeks) of extraction sockets exhibiting partial loss of the labial bone. Two extraction sockets of the maxillary incisors from each of six dogs were assigned to two treatment modalities: deproteinized bovine bone mineral (i) with 10% collagen (DBBM-C) soaked with HIF1A and covered by a collagen membrane (CM) (HIF group) or (ii) treated with DBBM-C only and covered by a CM (control group). Microcomputed tomography revealed some degree of collapse of the labial contour. The totally augmented volume and new bone volume did not differ significantly between two groups ( P > 0.05). The histological analysis revealed that the apical area of the socket was mostly filled with newly formed bone, while there was less newly formed bone in the coronal area and incomplete cortex formation. The histomorphometric analysis revealed that the area of newly formed bone was significantly larger in the HIF group than the control group (12.16 ± 3.04 versus 9.48 ± 2.01 mm 2 , P < 0.05), while there was no significant intergroup difference in the total augmented area. In conclusion, even though DBBM-C soaked with HIF1A enhanced histomorphometric bone formation, this intervention did not demonstrate superiority in preventing ridge shrinkage compared to DBBM-C alone. Clinical relevance of these findings should be further studied.

Published
2018
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