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Your search keyword '"Li, Xiao‐Kun"' showing total 6 results
Start Over Author "Li, Xiao‐Kun" Journal biomed research international
6 results on '"Li, Xiao‐Kun"'

2. Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

Author

Zhao, Hai-yang, Wu, Jiang, Zhu, Jing-jing, Xiao, Ze-cong, He, Chao-chao, Shi, Hong-xue, Li, Xiao-kun, Yang, Shu-lin, and Xiao, Jian

Subjects
Article Subject
Abstract

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor’s application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.

Published
2015
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3. Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

Author

Lin, Wei-hong, primary, Xiang, Li-Jun, additional, Shi, Hong-Xue, additional, Zhang, Jian, additional, Jiang, Li-ping, additional, Cai, Ping-tao, additional, Lin, Zhen-Lang, additional, Lin, Bei-Bei, additional, Huang, Yan, additional, Zhang, Hai-Lin, additional, Fu, Xiao-Bing, additional, Guo, Ding-Jiong, additional, Li, Xiao-Kun, additional, Wang, Xiao-Jie, additional, and Xiao, Jian, additional

Published
2015
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6. Fibroblast growth factors stimulate hair growth through β-catenin and Shh expression in C57BL/6 mice.

Author

Lin WH, Xiang LJ, Shi HX, Zhang J, Jiang LP, Cai PT, Lin ZL, Lin BB, Huang Y, Zhang HL, Fu XB, Guo DJ, Li XK, Wang XJ, and Xiao J

Subjects
Animals, Fibroblast Growth Factors pharmacology, Fibroblasts cytology, Gene Expression Regulation drug effects, Mice, Fibroblast Growth Factors metabolism, Fibroblasts metabolism, Gene Expression Regulation physiology, Hair Follicle growth & development, Hedgehog Proteins biosynthesis, beta Catenin biosynthesis
Abstract

Growth factors are involved in the regulation of hair morphogenesis and cycle hair growth. The present study sought to investigate the hair growth promoting activities of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the mechanism of action. We observed that FGFs promoted hair growth by inducing the anagen phase in telogenic C57BL/6 mice. Specifically, the histomorphometric analysis data indicates that topical application of FGFs induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to the control group. Moreover, the immunohistochemical analysis reveals earlier induction of β-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. These results suggest that FGFs promote hair growth by inducing the anagen phase in resting hair follicles and might be a potential hair growth-promoting agent.

Published
2015
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