1. Effect of Experimental Infection withHaemonchus contortuson Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats
- Author
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Willy Cei, P. J. Dumoulin, J. C. Bambou, N. Mandonnet, Thibaut Larcher, Unité de Recherches Zootechniques (URZ), Institut National de la Recherche Agronomique (INRA), Physiopathologie Animale et bioThérapie du muscle et du système nerveux (PAnTher), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Plateforme Tropicale d'Expérimentation sur l'Animal (PTEA), INRA, La Region Guadeloupe, and Le Conseil Regional de la Guadeloupe
- Subjects
SELECTION ,Veterinary medicine ,Article Subject ,[SDV]Life Sciences [q-bio] ,education ,lcsh:Medicine ,Abomasum ,General Biochemistry, Genetics and Molecular Biology ,030308 mycology & parasitology ,Feces ,03 medical and health sciences ,GASTROINTESTINAL NEMATODE PARASITES ,Eosinophilia ,medicine ,Parasite Egg Count ,Animals ,IMMUNE-RESPONSE ,MAST-CELL ,LAMBS ,030304 developmental biology ,0303 health sciences ,General Immunology and Microbiology ,biology ,Goats ,lcsh:R ,General Medicine ,Eosinophil ,biology.organism_classification ,EOSINOPHIL RESPONSES ,humanities ,VARIABILITY ,Mononuclear cell infiltration ,Nematode ,medicine.anatomical_structure ,SHEEP ,CHALLENGE ,Immunology ,Female ,Haemonchus ,medicine.symptom ,Haemonchiasis ,human activities ,Research Article ,Haemonchus contortus - Abstract
This study was carried out to evaluate the relationships of cellular changes in the abomasal mucosa and parasitological parameters, by comparing resistant and susceptible young Creole goats (kids) after experimental infection withHaemonchus contortus. The kids were infected over 2 periods (challenges 1 and 2) of 7 and 6 weeks, respectively. Fecal egg count (FEC), blood eosinophilia, packed cell volume (PCV), and body weight were weekly monitored. At the end of both challenges a subgroup of kids was slaughtered for nematode burden measurements and analysis of inflammatory cell infiltration in the abomasal mucosa. The average daily gain was higher in resistant kids after both challenges. Blood eosinophilia and FEC were higher in susceptible kids after both challenges. The number of immature worms and the means of female length were lower after challenge 2 whatever the genetic status. No differences were observed in the eosinophil and mononuclear cell infiltration between challenges 1 and 2 and resistant and susceptible kids. Globule leukocyte infiltration was found higher after the challenge 1 in resistant kids. This effect of the genetic status on globule leukocytes counts but not on the other inflammatory cell highlights the need for further study on the functional activity of these cell populations.
- Published
- 2013