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Start Over Author "Reich, Adam" Journal biomed research international
10 results on '"Reich, Adam"'

4. Prevalence of Pruritus in Cutaneous Lupus Erythematosus: Brief Report of a Multicenter, Multinational Cross-Sectional Study

Author

Samotij, Dominik, primary, Szczęch, Justyna, additional, Kushner, Carolyn J., additional, Mowla, Mohammad Rafiqul, additional, Dańczak-Pazdrowska, Aleksandra, additional, Antiga, Emiliano, additional, Chasset, François, additional, Furukawa, Fukumi, additional, Hasegawa, Minoru, additional, Hashizume, Hideo, additional, Islam, Aminul, additional, Ikeda, Takaharu, additional, Lesiak, Aleksandra, additional, Polańska, Adriana, additional, Misery, Laurent, additional, Szepietowski, Jacek C., additional, Tsuruta, Daisuke, additional, Adamski, Zygmunt, additional, Werth, Victoria P., additional, and Reich, Adam, additional

Published
2018
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5. UCHL1/PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch

Author

Kupczyk, Piotr, primary, Reich, Adam, additional, Gajda, Mariusz, additional, Hołysz, Marcin, additional, Wysokińska, Edyta, additional, Paprocka, Maria, additional, Nevozhay, Dmitry, additional, Chodaczek, Grzegorz, additional, Jagodziński, Paweł P., additional, Ziółkowski, Piotr, additional, and Szepietowski, Jacek C., additional

Published
2018
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10. UCHL1 /PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch.

Author

Kupczyk P, Reich A, Gajda M, Hołysz M, Wysokińska E, Paprocka M, Nevozhay D, Chodaczek G, Jagodziński PP, Ziółkowski P, and Szepietowski JC

Subjects
Adult, Aged, Epidermis, Female, Humans, Male, Middle Aged, Pruritus metabolism, Skin innervation, Young Adult, Keratinocytes metabolism, Psoriasis metabolism, Ubiquitin Thiolesterase metabolism
Abstract

Psoriasis is an immunogenetic skin disease manifesting as plaque lesions on the skin. Patients with psoriasis frequently suffer from itch, an unpleasant sensation causing a desire to scratch. Psoriatic itch is mainly transmitted by unmyelinated C-fibers; however, the exact molecular mechanism of psoriatic itch is still unexplained. Protein gene product 9.5 (PGP 9.5) is a panneurological marker commonly used for analysis of peripheral peptidergic and nonpeptidergic nerves and identification of cutaneous neuro-immune-endocrine cells. However, some studies suggested that nonneuronal cells, like keratinocytes, may also express PGP 9.5. This phenomenon might be linked with impaired axonal transport, keratinocyte injury, or dysfunctions of neuro-immune-cutaneous connections. The aim of this study was to analyze the expression of PGP 9.5 in psoriatic skin. We observed significantly altered density of PGP 9.5-positive axonal nerve terminals in pruritic lesional (p=0.04) and nonlesional psoriatic skin (p>0.001) compared with controls. In contrast, no significant differences were observed between psoriatic skin without itch and controls. Furthermore, PGP 9.5 expression by suprabasal keratinocytes (SBKs) was significantly increased in itchy skin lesions (p=0.007) compared to skin without itch, and a positive correlation was observed between PGP 9.5 expression and itch intensity (r=0.64; p=0.02). Our findings indicate changes in peripheral innervations and psoriatic keratinocytes, which may influence neuro-immune-cutaneous homeostasis and modulate itch transmission.

Published
2018
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