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Every year lots of different pesticides through various ways go to the environment . These pesticides are distributed to the environment and transported to the remote areas . To predict the effects of these substances on the ecosystem, in addition to information on their toxicity, how to enter, play and behavior of these compounds in nature should be well known . The purpose of this study was to determine the effect of oxydemeton methyl toxin on hormones testosterone and dihydrotestosterone in rats.For this purpose, 40 adult male Wistar rats, weighing approximately 19010 gr were divided into 5 groups of 8 . The groups include : Control group , sham and treatment with doses 2ppm , 5ppm , 10 ppm . Poison was fed to the animals orally daily for 14 days. At the end of the experimental period, animals were weighed, blood sampling was performed , and Blood samples were centrifuged to obtain serum and until hormone measurements was performed, it was frozen at the temperature of - 20 ° C . Concentration of hormone testosterone by RIA method and dihydrotestosterone by ELISA method were measured. The results of this study showed that use of oxydemeton methyl toxin in maximum for 14 days , causes significant decrease in concentration of hormones testosterone and dihydrotestosterone P