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Abstract Objective This study aims to use a wall shear stress (WSS) quantitative analysis software to analyze and evaluate the carotid sinus WSS spatial distribution and characteristics in intima-media thickness (IMT) normal and thickening group by using two-dimensional color doppler flow imaging (CDFI) so as to assist clinicians to predict the location and risk of plaque formation. Methods According to IMT, 50 subjects was selected as IMT thickening group and 50 subjects as IMT normal group from subjects who had a carotid ultrasound examination in Shanghai East hospital during October 2016 to October 2017. This study presents the spatial distribution of the carotid sinus WSS based on the WSS quantitative analysis software and compared the spatial distribution and characteristics of the carotid sinus WSS between IMT thickening group and IMT normal group through two- and three-dimensional WSS maps and a fused WSS image. Results The distributional regularity of WSS in both two group was: carotid sinus

Abstract Background Patients with uremia have high cardiovascular disease morbidity and mortality despite having normal left ventricular ejection fraction (LVEF). Longitudinal strain (LS) can be associated with subtle changes in LV systolic function. The aim of this study was to use two-dimensional speckle-tracking echocardiography (2DSTE) to assess subclinical LV myocardial dysfunction and to explore strain-changing regularities in uremic patients with LVEF ≥ 55%. Methods The study population included 40 uremic patients and 40 healthy volunteers. 2DSTE was performed on all participants to assess peak LS in the basal, mid and apical LV (BLS, MLS and ALS) and the respective time to peak LS (T-BLS, T-MLS, T-ALS). Results BLS, MLS, and ALS were significantly decreased in the uremic group relative to healthy controls and LS increased going in a basal to apical direction in both groups. T-BLS, T-MLS and T-ALS was significantly increased in the uremic group compared with the control group. In uremic patients, T-BLS, but not T-MLS or T-ALS, was significantly delayed relative to the control group. Bivariate analysis of creatinine (Cr) or urea nitrogen and strain parameters revealed a correlation only between ALS and Cr. Conclusion 2DSTE can identify LV myocardial abnormalities in uremic patients with preserved LVEF at early stage, as well as some changing regularities of LS and T-LS in the left ventricle.