1. Towards an ideal source of mesenchymal stem cell isolation for possible therapeutic application in regenerative medicine.
- Author
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Bellavia M, Altomare R, Cacciabaudo F, Santoro A, Allegra A, Concetta Gioviale M, and Lo Monte AI
- Subjects
- Adipose Tissue cytology, Amniotic Fluid cytology, Bone Marrow Cells cytology, Chorionic Villi, Female, Humans, Placenta cytology, Pregnancy, Mesenchymal Stem Cells cytology, Regenerative Medicine methods
- Abstract
Background: The possibility of obtaining mesenchymal stem cells (MSCs) from fetal tissue such as amniotic fluid, chorionic villi and placenta is well-known and a comparison between MSCs originating in different sources such as fetal tissue and those from bone marrow in terms of yield and function is a topical issue. The mesenchymal stem cells isolated from bone marrow are well-characterized. Unfortunately the low quantitative yield during isolation is a major problem. For this reason, other tissue sources for MSCs are of paramount importance., Conclusion: In this review, starting from a description of the molecular and cellular biology of MSCs, we describe alternative sources of isolation other than bone marrow. Finally, we describe the potential therapeutic application of these cells.
- Published
- 2014
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