1. Secreted frizzled-related proteins: A promising therapeutic target for cancer therapy through Wnt signaling inhibition.
- Author
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Zhang, Wenqiang, Zhang, Kexin, Ma, Yanhui, Song, Yixin, Qi, Tongbing, Xiong, Guoji, Zhang, Yuanzhu, Kan, Chengxia, Zhang, Jingwen, Han, Fang, and Sun, Xiaodong
- Subjects
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SECRETED frizzled-related proteins , *WNT signal transduction , *DRUG target , *CANCER treatment , *PROGNOSIS - Abstract
The Wnt signaling system is a critical pathway that regulates embryonic development and adult homeostasis. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or Frizzled receptors. SFRPs can act as anti-Wnt agents and suppress cancer growth by blocking the action of Wnt ligands. However, SFRPs are often silenced by promoter methylation in cancer cells, resulting in hyperactivation of the Wnt pathway. Epigenetic modifiers can reverse this silencing and restore SFRPs expression. Despite the potential of SFRPs as a therapeutic target, the effects of SFRPs on tumor development remain unclear. Therefore, a review of the expression of various members of the SFRPs family in different cancers and their potential as therapeutic targets is warranted. This review aims to summarize the current knowledge of SFRPs in cancer, focusing on their expression patterns and their potential as novel therapeutic targets. [Display omitted] ● SFRPs as diagnostic/prognostic biomarkers in cancers. ● SFRPs sensitize cancer cells to chemotherapy and radiotherapy ● SFRPs enhance immune responses and modulate tumor microenvironment. ● Combined SFRPs therapies with chemo/immunotherapy hold cancer therapy potential. ● Epigenetic modifiers restore SFRPs expression, a promising cancer therapy target. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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