1. Stimulator of interferon genes (STING): Key therapeutic targets in ischemia/reperfusion injury.
- Author
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Lv, Juan, Zhu, Xuanxuan, Xing, Chunlei, Chen, Yuhong, Bian, Huihui, Yin, Heng, Gu, Xiaofeng, and Su, Li
- Subjects
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REPERFUSION injury , *PATTERN perception receptors , *KILLER cells , *DRUG target , *ISCHEMIA , *MYOCARDIAL infarction , *KIDNEY transplantation - Abstract
The Stimulator of Interferon Genes (STING) is predominantly expressed in immune cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a pattern recognition receptor. STING activation upon detecting cytosolic DNA released from damaged cells initiates downstream pathways, leading to the production of inflammatory cytokines such as IFNs, IL-6, and TNF-α. Dysregulated STING activation has been implicated in inflammatory and metabolic diseases. Ischemia/reperfusion injury (I/RI) is common in stroke, acute myocardial infarction, organ transplantation, and surgeries for certain end-stage diseases. Recent studies suggest that STING could be a novel therapeutic target for I/RI treatment. In this review, we provide a concise overview of the cGAS-STING signaling pathway's general functions and summarize STING's role in I/RI across various organs, including the heart, liver, kidney, and lung. Moreover, we explore potential therapeutic approaches for I/RI by targeting STING. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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