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Your search keyword '"Tang, Jianwu"' showing total 16 results
Start Over Author "Tang, Jianwu" Journal biomedicine & pharmacotherapy
16 results on '"Tang, Jianwu"'

15. Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis.

Author

Du, Yue, Huang, Yuhong, Gao, Yue, Song, Bo, Mao, Jun, Chen, Lina, Bai, Lulu, and Tang, Jianwu

Subjects
*LIVER cancer, *ANNEXINS, *PROTEIN binding, *MITOCHONDRIAL membranes, *APOPTOSIS, *LABORATORY mice, *GENETICS
Abstract

Annexin A7 caused an anti-apoptosis phenotype in mouse hepatocarcinoma cells. Yet, the underlying mechanism remains unclear. In this study, we found that Annexin A7 had an inhibitory effect on the mitochondrial Cytochrome C release and Caspase-3 cleavage. Furthermore, Annexin A7 was identified to form a complex with BAG4 which is a negative regulator of apoptosis. Moreover, Annexin A7 was positively correlated with the protein levels of BAG4, Hsp70 and Bcl-2. Both Hsp70 and Bcl-2 bind BAG4 and inhibit Cytochrom C dependent activation of Caspase-3. Taken together, our study indicated Annexin A7 modulated BAG4 and BAG4-binding proteins in mitochondrial apoptosis. [ABSTRACT FROM AUTHOR]

Published
2015
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16. Evaluation of Annexin A7, Galectin-3 and Gelsolin as possible biomarkers of hepatocarcinoma lymphatic metastasis.

Author

Wang, Xianyan, YueGao, Bai, Lulu, Ibrahim, Mohammed Mohammed, Ma, Wei, Zhang, Jun, Huang, Yuhong, Wang, Bo, Song, Lin, and Tang, Jianwu

Subjects
*ANNEXINS, *GALECTINS, *GELSOLIN, *THERAPEUTIC use of biochemical markers, *LIVER cancer, *LYMPHATIC metastasis, *IN vitro studies
Abstract

Abstract: We have previously demonstrated that Annexin A7 is involved in the lymphatic metastasis of hepatocarcinoma in vitro. The expression of Galectin-3 and Gelsolin, which were also relevant to tumor lymphatic metastasis, had shown the same tendency concordantly with the expression of Annexin A7 alteration by qRT-PCR and Western blot analysis. Here, we gain an insight into the role that Annexin A7 is playing in Hca-P, PAnxa7-upregulated and PAnxa7-downregulated cells in vivo. Then, Hca-P, PAnxa7-upregulated and PAnxa7-downregulated cells were injected into a mouse footpad to establish primary tumors in mice. On the fourth week after HCC cells inoculation, the mice were sacrificed for inspection the expression of Annexin A7, Galectin-3 and Gelsolin in primary tumors and in serum. Our work indicates that Annexin A7 and Gelsolin are both valuable in tumors and in serum evaluating lymph node metastasis in mice with hepatocarcinoma; Galectin-3 in tumors is significant but no much contribution in serum. [Copyright &y& Elsevier]

Published
2014
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