Search

Your search keyword '"Yousefi, Mehdi"' showing total 25 results
Start Over Author "Yousefi, Mehdi" Journal biomedicine & pharmacotherapy
25 results on '"Yousefi, Mehdi"'

5. The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple sclerosis

Author

Hashemi, Behnam, primary, Abdollahi, Maryam, additional, Abbaspour-Aghdam, Sanaz, additional, Hazrati, Ali, additional, Malekpour, Kosar, additional, meshgi, Shahla, additional, Kafil, Hossein Samadi, additional, ghazi, Farhood, additional, Yousefi, Mehdi, additional, Roshangar, Leila, additional, and Ahmadi, Majid, additional

Published
2023
Full Text
View/download PDF

24. The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer.

Author

Masjedi, Ali, Hashemi, Vida, Hojjat-Farsangi, Mohammad, Ghalamfarsa, Ghasem, Azizi, Gholamreza, Yousefi, Mehdi, and Jadidi-Niaragh, Farhad

Subjects
*INTERLEUKIN-6, *CELLULAR signal transduction, *BREAST cancer treatment, *CANCER invasiveness, *TUMOR growth, *ANTINEOPLASTIC agents
Abstract

Highlights • IL-6 and its associated signaling promote cancer progression. • Targeting IL-6 signaling axis can arrest tumor growth. • Blockage of IL-6 and IL-6R can be considered as a new anti-cancer approach. Abstract Despite remarkable improvements in cancer treatment approaches, breast cancer is still the main cause of cancer-related death in women. Its principal cause is the resistance of the cancer cells against conventional anticancer therapeutics, mainly in advanced disease stages. It has been shown that chronic inflammation in the tumor microenvironment facilitates tumor growth and induces resistance toward chemo- and radiotherapy. Overexpression of interleukin-6 (IL-6) cytokine in the tumor microenvironment has been demonstrated in numerous tumors including breast cancer. Tumor cells and tumor-associated fibroblasts are the major sources of IL-6 secretion in the tumor microenvironment. Several studies have demonstrated the immunopathogenic function of IL-6 and its signaling in the tumor growth, metastasis, and therapeutic resistance in the breast cancer. Therefore, it seems that targeting IL-6 and/or its receptor in combination with other potent anticancer therapies may be a potent therapeutic approach for breast cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

25. MicroRNA-induced drug resistance in gastric cancer.

Author

Dehghanzadeh, Rashedeh, Jadidi-Niaragh, Farhad, Gharibi, Tohid, and Yousefi, Mehdi

Subjects
*GASTROINTESTINAL cancer treatment, *MICRORNA, *DRUG resistance in cancer cells, *GASTROINTESTINAL cancer, *BIOCHEMICAL mechanism of action, *ANTINEOPLASTIC agents, *PATIENTS
Abstract

Drug resistance remains one of the major reasons of therapy failure in gastric cancer patients. Although the mechanisms of anticancer drug resistance have been broadly investigated, they have not been completely understood. Accumulating reports have recently highlighted the involvement of endogenous non-coding RNAs, known as microRNAs, in the evolution of cancer cell drug resistance. MiRNAs have been characterized as major regulators of crucial genes implicated in the chemoresistance phenotype of gastric cancer cells. MiRNA-based therapy in the future may provide a new strategy to overcome drug resistance. This review summarizes the current knowledge on the role of miRNAs in regulating drug resistance in gastric cancer and their potential to develop targeted therapies and personalized treatment for managing drug resistant gastric cancers. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results